Major League Baseball is one of the Intellivision's most celebrated sports titles, delivering a remarkably realistic baseball simulation for its time. Players control every aspect of the game, from pitching and batting to fielding, base running, steals, and double plays, across a full nine-inning contest. Originally released by Mattel Electronics under an official Major League Baseball license, the game was later republished by INTV Corporation as Big League Baseball after acquiring the Intellivision product line, with the only significant change being the removal of the MLB branding. As the best-selling Intellivision cartridge ever released, it helped establish the console's reputation as the premier home system for sports games.

One interesting trivia fact is that Major League Baseball is the only original Intellivision game to feature synthesized speech without requiring the Intellivoice module—the umpire's memorable call of "Yer out!" is generated directly by the console's sound chip.